Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Neurodegenerative disorders

Neural synchronization in Alzheimer's disease

Electrical oscillations generated by neural circuits are disrupted in Alzheimer's disease. Restoring these oscillations in mouse models activates immune cells to clear disease-associated amyloid-β protein from the brain. See Article p.230

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Gamma oscillations stimulate the clearance of amyloid-β protein deposits.

Notes

  1. See all news & views

References

  1. Wang, X.-J. Physiol. Rev. 90, 1195–1268 (2010).

    Article  Google Scholar 

  2. Uhlhaas, P. J. & Singer, W. Neuron 52, 155–168 (2006).

    Article  CAS  Google Scholar 

  3. Iaccarino, H. F. et al. Nature 540, 230–235 (2016).

    Article  ADS  CAS  Google Scholar 

  4. Koenig, T. et al. Neurobiol. Aging 26, 165–171 (2005).

    Article  CAS  Google Scholar 

  5. Pijnenburg, Y. A. L. et al. Clin. Neurophysiol. 115, 1332–1339 (2004).

    Article  CAS  Google Scholar 

  6. Palop, J. J. et al. Neuron 55, 697–711 (2007).

    Article  CAS  Google Scholar 

  7. Verret, L. et al. Cell 149, 708–721 (2012).

    Article  CAS  Google Scholar 

  8. Gillespie, A. K. et al. Neuron 90, 740–751 (2016).

    Article  CAS  Google Scholar 

  9. Sohal, V. S., Zhang, F., Yizhar, O. & Deisseroth, K. Nature 459, 698–702 (2009).

    Article  ADS  CAS  Google Scholar 

  10. Fries, P., Nikolić, D. & Singer, W. Trends Neurosci. 30, 309–316 (2007).

    Article  CAS  Google Scholar 

  11. Palop, J. J. & Mucke, L. Nature Neurosci. 13, 812–818 (2010).

    Article  CAS  Google Scholar 

  12. Cirrito, J. R. et al. Neuron 48, 913–922 (2005).

    Article  CAS  Google Scholar 

  13. Brettschneider, J., Del Tredici, K., Lee, V. M.-Y. & Trojanowski, J. Q. Nature Rev. Neurosci. 16, 109–120 (2015).

    Article  CAS  Google Scholar 

  14. Pooler, A. M. et al. Alzheimers Res. Ther. 5, 49 (2013).

    Article  Google Scholar 

  15. Yankner, B. A., Lu, T. & Loerch, P. Annu. Rev. Pathol. 3, 41–66 (2008).

    Article  CAS  Google Scholar 

  16. Hong, S., Dissing-Olesen, L. & Stevens, B. Curr. Opin. Neurobiol. 36, 128–134 (2015).

    Article  Google Scholar 

  17. Hong, S. et al. Science 352, 712–716 (2016).

    Article  ADS  CAS  Google Scholar 

  18. Lutz, A., Greischar, L. L., Rawlings, N. B., Ricard, M. & Davidson, R. J. Proc. Natl Acad. Sci. USA 101, 16369–16373 (2004).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Bruce A. Yankner.

Related audio

Related links

Related links

Related links in Nature Research

Alzheimer's disease: Attack on amyloid-β protein

Alzheimer's disease: A protective factor for the ageing brain

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Aron, L., Yankner, B. Neural synchronization in Alzheimer's disease. Nature 540, 207–208 (2016). https://doi.org/10.1038/540207a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/540207a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing