Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Evolution

Genomic remodelling in the primate brain

In many mammals, the gene Ostn is expressed in muscles and bones. The discovery that the primate OSTN gene has been repurposed to also act in neurons provides clues to how humans evolved their cognitive abilities. See Article p.242

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: A gene repurposed.

Notes

  1. See all news & views

References

  1. Carroll, S. B. Nature 422, 849–857 (2003).

    Article  ADS  CAS  Google Scholar 

  2. Petanjek, Z. et al. Proc. Natl Acad. Sci. USA 108, 13281–13286 (2011).

    Article  ADS  CAS  Google Scholar 

  3. Greer, P. L. & Greenberg, M. E. Neuron 59, 846–860, (2008).

    Article  CAS  Google Scholar 

  4. Ataman, B. et al. Nature 539, 242–247 (2016).

    Article  ADS  Google Scholar 

  5. Kim, T. K. et al. Nature 465, 182–187 (2010).

    Article  ADS  CAS  Google Scholar 

  6. Lanahan, A. & Worley, P. Neurobiol. Learn. Mem. 70, 37–43 (1998).

    Article  CAS  Google Scholar 

  7. Hughes, P., Beilharz, E., Gluckman, P. & Dragunow, M. Neuroscience 57, 319–328 (1993).

    Article  CAS  Google Scholar 

  8. Moffatt, P. et al. J. Biol. Chem. 282, 36454–36462 (2007).

    Article  CAS  Google Scholar 

  9. Subbotina, E. et al. Proc. Natl Acad. Sci. USA 112, 16042–16047 (2015).

    Article  ADS  CAS  Google Scholar 

  10. Flavell, S. W. et al. Science 311, 1008–1012 (2006).

    Article  ADS  CAS  Google Scholar 

  11. Mao, Z., Bonni, A., Xia, F., Nadal-Vicens, M. & Greenberg, M. E. Science 286, 785–790 (1999).

    Article  CAS  Google Scholar 

  12. Zhao, Z. & Ma, L. Proc. Natl Acad. Sci. USA 106, 18016–18021 (2009).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Justine Kupferman or Franck Polleux.

Related links

Related links

Related links in Nature Research

Neurobiology: Building a bigger brain

https://doi.org/10.1038/498044

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Kupferman, J., Polleux, F. Genomic remodelling in the primate brain. Nature 539, 171–172 (2016). https://doi.org/10.1038/539171a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/539171a

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing