Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Stem cells

Bone cells on demand

Subjects

Researchers have come up with a simple recipe for making bone from stem cells.

Embryonic stem cells can form every type of tissue in the body, but methods for forcing these and other pluripotent stem cells to differentiate into a specific type can be inefficient and costly. A team led by Shyni Varghese at the University of California, San Diego, added a chemical called adenosine — which occurs naturally in the body — to human stem-cell cultures and produced bone-making cells called osteoblasts in under three weeks. The cultured osteoblasts generated calcified bone, and scaffolds that had been coated with the osteoblasts and implanted into mice repaired skull defects.

Sci. Adv. 2, e1600691 (2016)

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Bone cells on demand. Nature 537, 141 (2016). https://doi.org/10.1038/537141c

Download citation

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing