News & Views | Published:

Physiology

Stressed-out chromatin promotes longevity

Nature volume 534, pages 625626 (30 June 2016) | Download Citation

Two studies reveal that early-life malfunction in organelles called mitochondria brings about lasting changes in how DNA is packaged. These alterations have consequences for cellular stress responses and organismal longevity.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , & Science 298, 830–834 (2002).

  2. 2.

    , & PLoS Biol. 5, e259 (2007).

  3. 3.

    & J. Cell Sci. 123, 3849–3855 (2010).

  4. 4.

    , & Cell 144, 79–91 (2011).

  5. 5.

    et al. Cell 165, 1197–1208 (2016).

  6. 6.

    et al. Cell 165, 1209–1223 (2016).

  7. 7.

    , , , & Dev. Cell 13, 467–480 (2007).

  8. 8.

    , & Free Radic. Biol. Med. 78, 168–178 (2015).

  9. 9.

    & Mol. Cell 59, 639–650 (2015).

  10. 10.

    , & Cell Metab. 17, 954–964 (2013).

Download references

Author information

Affiliations

  1. Siu Sylvia Lee is in the Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14850, USA.

    • Siu Sylvia Lee
  2. Jessica K. Tyler is in the Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York 10065, USA.

    • Jessica K. Tyler

Authors

  1. Search for Siu Sylvia Lee in:

  2. Search for Jessica K. Tyler in:

Corresponding authors

Correspondence to Siu Sylvia Lee or Jessica K. Tyler.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/534625a

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing