Research Highlights | Published:

Neuroscience

Microbe makes mice social

Nature volume 534, pages 438439 (23 June 2016) | Download Citation

Female mice that eat a high-fat diet produce litters with social deficits that are linked to changes in the offspring's gut bacteria.

Mauro Costa-Mattioli at Baylor College of Medicine in Houston, Texas, and his colleagues compared offspring from mothers that ate a high-fat diet with those from mothers on a normal diet. The high-fat-diet offspring spent less time interacting with other mice, and had reduced bacterial diversity in their guts. In the animals' brains, researchers found fewer neurons containing oxytocin, a hormone that is related to social behaviour. Electrical signalling in the ventral tegmental area, a brain region that processes rewarding stimuli, did not strengthen as it normally does following new social interactions.

The team identified a gut bacterium, Lactobacillus reuteri, that reversed these abnormalities when it was given to the high-fat-diet offspring.

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https://doi.org/10.1038/534438e

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