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Physiology

Microbial signals to the brain control weight

The bacteria that inhabit the rodent gut promote insulin secretion and food intake by activating the parasympathetic nervous system — a hitherto unknown mode of action for this multifaceted microbiota. See Article p.213

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Figure 1: A mechanism for microbiota-mediated weight gain.

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References

  1. Sommer, F. & Bäckhed, F. Nature Rev. Microbiol. 11, 227–238 (2013).

    Article  CAS  Google Scholar 

  2. Perry, R. J. et al. Nature 534, 213–217 (2016).

    Article  ADS  CAS  Google Scholar 

  3. de Lartigue, G. J. Physiol. (Lond.) http://dx.doi.org/10.1113/JP271538 (2016).

  4. Bereiter, D. A., Berthoud, H. R., Brunsmann, M. & Jeanrenaud, B. Am. J. Physiol. 241, E22–E27 (1981).

    CAS  PubMed  Google Scholar 

  5. Priyadarshini, M., Wicksteed, B., Schiltz, G. E., Gilchrist, A. & Layden, B. T. Trends Endocrinol. Metab. http://dx.doi.org/10.1016/j.tem.2016.03.011 (2016).

  6. Turnbaugh, P. J. et al. Nature 444, 1027–1031 (2006).

    Article  ADS  Google Scholar 

  7. Koren, O. et al. Cell 150, 470–480 (2012).

    Article  CAS  Google Scholar 

  8. Chevalier, C. et al. Cell 163, 1360–1374 (2015).

    Article  CAS  Google Scholar 

  9. Bäckhed, F. et al. Proc. Natl Acad. Sci. USA 101, 15718–15723 (2004).

    Article  ADS  Google Scholar 

  10. Suárez-Zamorano, N. et al. Nature Med. 21, 1497–1501 (2015).

    Article  Google Scholar 

  11. De Vadder, F. et al. Cell 156, 84–96 (2014).

    Article  CAS  Google Scholar 

  12. Reyes, A., Semenkovich, N. P., Whiteson, K., Rohwer, F. & Gordon, J. I. Nature Rev. Microbiol. 10, 607–617 (2012).

    Article  CAS  Google Scholar 

  13. Petrof, E. O. & Khoruts, A. Gastroenterology 146, 1573–1582 (2014).

    Article  Google Scholar 

Download references

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Correspondence to Mirko Trajkovski or Claes B. Wollheim.

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Trajkovski, M., Wollheim, C. Microbial signals to the brain control weight. Nature 534, 185–187 (2016). https://doi.org/10.1038/534185a

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