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Cancer genomics

Hard-to-reach repairs

Two studies find that the molecular machinery that initiates gene transcription prevents repair proteins from accessing DNA, resulting in increased mutation rates at sites of transcription-factor binding. See Letters p.259 & p.264

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Correspondence to Ekta Khurana.

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Khurana, E. Hard-to-reach repairs. Nature 532, 181–182 (2016). https://doi.org/10.1038/532181a

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