Two studies find that the molecular machinery that initiates gene transcription prevents repair proteins from accessing DNA, resulting in increased mutation rates at sites of transcription-factor binding. See Letters p.259 & p.264
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Sabarinathan, R., Mularoni, L., Deu-Pons, J., Gonzalez-Perez, A. & López-Bigas, N. Nature 532, 264–267 (2016).
Perera, D. et al. Nature 532, 259–263 (2016).
Khurana, E. et al. Nature Rev. Genet. 17, 93–108, (2016).
Horn, S. et al. Science 339, 959–961 (2013).
Huang, F. W. et al. Science 339, 957–959, (2013).
Khurana, E. et al. Science 342, 1235587 (2013).
Hu, J., Adar, S., Selby, C. P., Lieb, J. D. & Sancar, A. Genes Dev. 29, 948–960 (2015).
Polak, P. et al. Nature Biotechnol. 32, 71–75 (2014).
Schuster-Böckler, B. & Lehner, B. Nature 488, 504–507 (2012).
Lawrence, M. S. et al. Nature 499, 214–218, (2013).
Supek, F. & Lehner, B. Nature 521, 81–84 (2015).
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Khurana, E. Hard-to-reach repairs. Nature 532, 181–182 (2016). https://doi.org/10.1038/532181a
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DOI: https://doi.org/10.1038/532181a