Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


The X-Files of hepatitis B

The HBx protein of hepatitis B virus has been found to co-opt a host-cell enzyme that targets the Smc5/6 protein complex for degradation. The finding identifies Smc5/6 as a cellular antiviral factor. See Letter p.386

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Hepatitis B virus evasion of cellular antiviral function.


  1. See all news & views


  1. Decorsière, A. et al. Nature 531, 386–389 (2016).

    Article  ADS  Google Scholar 

  2. Zoulim, F., Saputelli, J. & Seeger, C. J. Virol. 68, 2026–2030 (1994).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Zhang, Z., Torii, N., Hu, Z., Jacob, J. & Liang, T. J. J. Clin. Invest. 108, 1523–1531 (2001).

    Article  CAS  Google Scholar 

  4. Lee, T.-H., Elledge, S. J. & Butel, J. S. J. Virol. 69, 1107–1114 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Bosu, D. R. & Kipreos, E. T. Cell Div. 3, 7 (2008).

    Article  Google Scholar 

  6. Randow, F. & Lehner, P. J. Nature Cell Biol. 11, 527–534 (2009).

    Article  CAS  Google Scholar 

  7. Emanuele, M. J. et al. Cell 147, 459–474 (2011).

    Article  CAS  Google Scholar 

  8. Tavalai, N. & Stamminger, T. Virus Res. 157, 128–133 (2011).

    Article  CAS  Google Scholar 

  9. Wiebe, M. S. & Jamin, A. J. Virol. (2016).

  10. Stenglein, M. D., Burns, M. B., Li, M., Lengyel, J. & Harris, R. S. Nature Struct. Mol. Biol. 17, 222–229 (2010).

    Article  CAS  Google Scholar 

  11. Lucifora, J. et al. Science 343, 1221–1228 (2014).

    Article  ADS  CAS  Google Scholar 

  12. Kegel, A. & Sjögren, C. Cold Spring Harb. Symp. Quant. Biol. 75, 179–187 (2010).

    Article  CAS  Google Scholar 

  13. Levrero, M. et al. J. Hepatol. 51, 581–592 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to T. Jake Liang.

Related links

Related links

Related links in Nature Research

Cell biology: Beneficial lessons from viruses

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Liang, T. The X-Files of hepatitis B. Nature 531, 313–314 (2016).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing