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Virology

The X-Files of hepatitis B

The HBx protein of hepatitis B virus has been found to co-opt a host-cell enzyme that targets the Smc5/6 protein complex for degradation. The finding identifies Smc5/6 as a cellular antiviral factor. See Letter p.386

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Figure 1: Hepatitis B virus evasion of cellular antiviral function.

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Correspondence to T. Jake Liang.

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Liang, T. The X-Files of hepatitis B. Nature 531, 313–314 (2016). https://doi.org/10.1038/531313a

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