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Virology

The X-Files of hepatitis B

Nature volume 531, pages 313–314 (2016)Cite this article

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The HBx protein of hepatitis B virus has been found to co-opt a host-cell enzyme that targets the Smc5/6 protein complex for degradation. The finding identifies Smc5/6 as a cellular antiviral factor. See Letter p.386

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Figure 1: Hepatitis B virus evasion of cellular antiviral function.

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References

  1. Decorsière, A. et al. Nature 531, 386–389 (2016).

    Article  ADS  Google Scholar 

  2. Zoulim, F., Saputelli, J. & Seeger, C. J. Virol. 68, 2026–2030 (1994).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Zhang, Z., Torii, N., Hu, Z., Jacob, J. & Liang, T. J. J. Clin. Invest. 108, 1523–1531 (2001).

    Article  CAS  Google Scholar 

  4. Lee, T.-H., Elledge, S. J. & Butel, J. S. J. Virol. 69, 1107–1114 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Bosu, D. R. & Kipreos, E. T. Cell Div. 3, 7 (2008).

    Article  Google Scholar 

  6. Randow, F. & Lehner, P. J. Nature Cell Biol. 11, 527–534 (2009).

    Article  CAS  Google Scholar 

  7. Emanuele, M. J. et al. Cell 147, 459–474 (2011).

    Article  CAS  Google Scholar 

  8. Tavalai, N. & Stamminger, T. Virus Res. 157, 128–133 (2011).

    Article  CAS  Google Scholar 

  9. Wiebe, M. S. & Jamin, A. J. Virol. http://dx.doi.org/10.1128/JVI.00178-16 (2016).

  10. Stenglein, M. D., Burns, M. B., Li, M., Lengyel, J. & Harris, R. S. Nature Struct. Mol. Biol. 17, 222–229 (2010).

    Article  CAS  Google Scholar 

  11. Lucifora, J. et al. Science 343, 1221–1228 (2014).

    Article  ADS  CAS  Google Scholar 

  12. Kegel, A. & Sjögren, C. Cold Spring Harb. Symp. Quant. Biol. 75, 179–187 (2010).

    Article  CAS  Google Scholar 

  13. Levrero, M. et al. J. Hepatol. 51, 581–592 (2009).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. T. Jake Liang is in the Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1800, USA.,

    T. Jake Liang

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  1. T. Jake Liang
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Correspondence to T. Jake Liang.

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Liang, T. The X-Files of hepatitis B. Nature 531, 313–314 (2016). https://doi.org/10.1038/531313a

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