In mice, a high-fat diet has now been found to induce intestinal progenitor cells to adopt a more stem-cell-like fate, altering the size of the gut and increasing tumour incidence. See Article p.53
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References
Nihaylova, M. M., Sabatini, D. M. & Yilmaz, O. H. Cell Stem Cell 14, 292–305 (2014).
Nakada, D., Levi, B. P. & Morrison, S. J. Neuron 70, 703–718 (2011).
Shyh-Chang, N., Daley, G. Q. & Cantley, L. C. Development 140, 2535–2547 (2013).
Beyaz, S. et al. Nature 531, 53–58 (2016).
Sato, T. et al. Nature 469, 415–418 (2011).
Yalmaz, O. H. et al. Nature 486, 490–495 (2012).
Kesse, E., Clavel-Chapelon, F. & Boutron-Ruault, M. Am. J. Epidemiol. 164, 1085–1093 (2006).
Magee, J. A., Piskounova, E. & Morrison, S. J. Cancer Cell 21, 283–296 (2012).
Nelson, E. R. et al. Science 342, 1094–1098 (2013).
He, T.-C., Chan, T. A., Vogelstein, B. & Kinzler, K. W. Cell 99, 335–345 (1999).
Gruber, L. et al. PLoS ONE 8, e71661 (2013).
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Luo, C., Puigserver, P. Dietary fat promotes intestinal dysregulation. Nature 531, 42–43 (2016). https://doi.org/10.1038/531042a
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DOI: https://doi.org/10.1038/531042a
