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Epigenetics

A new methyl mark on messengers

The presence of an N1 methyl group on adenine bases in DNA and RNA was thought to be a form of damage. Results now show that it also occurs at specific sites in messenger RNAs, where it affects protein expression. See Article p.441

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Figure 1: Dynamic methylation of adenine.

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Correspondence to Anna M. Kietrys or Eric T. Kool.

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Kietrys, A., Kool, E. A new methyl mark on messengers. Nature 530, 423–424 (2016). https://doi.org/10.1038/530423a

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