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A new methyl mark on messengers

The presence of an N1 methyl group on adenine bases in DNA and RNA was thought to be a form of damage. Results now show that it also occurs at specific sites in messenger RNAs, where it affects protein expression. See Article p.441

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Figure 1: Dynamic methylation of adenine.


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  1. Meyer, K. D. & Jaffrey, S. R. Nature Rev. Mol. Cell Biol. 15, 313–326 (2014).

    CAS  Article  Google Scholar 

  2. Fu, Y., Dominissini, D., Rechavi, G. & He, C. Nature Rev. Genet. 15, 293–306 (2014).

    CAS  Article  Google Scholar 

  3. Edelheit, S., Schwartz, S., Mumbach, M. R., Wurtzel, O. & Sorek, R. PLoS Genet. 9, e1003602 (2013).

    CAS  Article  Google Scholar 

  4. Dominissini, D. et al. Nature 530, 441–446 (2016).

    CAS  ADS  Article  Google Scholar 

  5. Mishima, E. et al. J. Am. Soc. Nephrol. 25, 2316–2326 (2014).

    CAS  Article  Google Scholar 

  6. Helm, M., Giegé, R. & Florentz, C. Biochemistry 38, 13338–13346 (1999).

    CAS  Article  Google Scholar 

  7. He, C. et al. Mol. Cell 20, 117–129 (2005).

    CAS  Article  Google Scholar 

  8. Macon, J. B. & Wolfenden, R. Biochemistry 7, 3453–3458 (1968).

    CAS  Article  Google Scholar 

  9. Singer, B. & Grunberger, D. Molecular Biology of Mutagens and Carcinogens (Plenum, 1983).

    Book  Google Scholar 

  10. Aas, P. A. et al. Nature 421, 859–863 (2003).

    CAS  ADS  Article  Google Scholar 

  11. Li, X. et al. Nature Chem. Biol. (2016).

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Correspondence to Anna M. Kietrys or Eric T. Kool.

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Kietrys, A., Kool, E. A new methyl mark on messengers. Nature 530, 423–424 (2016).

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