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Developmental biology

Females have a lot of guts

The discovery of sex-biased proliferation in the intestinal stem cells of fruit-fly midguts reveals that the organ's size is determined by a previously undefined, sex-specific molecular pathway. See Letter p.344

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Figure 1: Sex and the gut.


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  1. Reiff, T. et al. eLife 4, e06930 (2015).

    Article  Google Scholar 

  2. Hudry, B., Khadayate, S. & Miguel-Aliaga, I. Nature 530, 344–348 (2016).

    Article  CAS  ADS  Google Scholar 

  3. Clough, E. & Oliver, B. Brief. Funct. Genomics 11, 387–394 (2012).

    Article  CAS  Google Scholar 

  4. Lynch, K. W. & Maniatis, T. Genes Dev. 10, 2089–2101 (1996).

    Article  CAS  Google Scholar 

  5. Bryant, P. J. Novartis Found. Symp. 237, 182–202 (2001).

  6. Silverman, G. A. et al. J. Biol. Chem. 285, 24299–24305 (2010).

    Article  CAS  Google Scholar 

  7. Rideout, E. J., Narsaiya, M. S. & Grewal, S. S. PLoS Genet. 11, e1005683 (2015).

    Article  Google Scholar 

  8. Brown, J. B. et al. Nature 512, 393–399 (2014).

    Article  CAS  ADS  Google Scholar 

  9. El Ouaamari, A. et al. Cell Metab. 23, 194–205 (2016).

    Article  CAS  Google Scholar 

  10. Mackay, T. F. C. Phil. Trans. R. Soc. Lond. 365, 1229–1239 (2010).

    Article  CAS  Google Scholar 

  11. Arnold, A. P. Biol. Sex Differ. 1, 1 (2010).

    Article  Google Scholar 

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Correspondence to Brian Oliver.

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Fear, J., Oliver, B. Females have a lot of guts. Nature 530, 289–290 (2016).

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