Drug discovery: A life of tumult and triumph

Marian Turner reviews the memoir of émigré virologist and millionaire philanthropist Jan Vilcek.

Love and Science: A Memoir

Seven Stories: 2016. 9781609806682 | ISBN: 978-1-6098-0668-2

Medical students in communist Czechoslovakia in the early 1950s were taught that Mendelian genetics was “bourgeois pseudoscience”. The theory of heredity that toed the party line came from Soviet agronomist Trofim Lysenko: Stalin championed his idea that acquired traits could be inherited. Jan Vilcek was one of several students of the time who saw through this nonsense, but kept quiet. The budding virologist already had two decades of experience of staying under the authoritarian radar — a frustration that would later prompt him to break free in spectacular fashion.

In Love and Science, Vilcek traces that tumultuous, ultimately triumphant journey. He takes us from his birth in 1933, to Jewish parents in Bratislava (in what is now Slovakia), to his current position of president and co-founder, with his art-historian wife Marica, of the Vilcek Foundation in New York City. This multimillion-dollar philanthropic enterprise uses Vilcek's royalties from the autoimmune drug Remicade (infliximab) to honour the contribution of immigrant scientists and artists to US society.

Jan Vilcek at medical school in Bratislava in the 1950s. Credit: Jan Vilcek's Personal Archives

Vilcek begins with how he discovered the drug. He cut his research teeth on interferons — proteins produced in response to infection — at the Bratislava Institute of Virology in the early 1960s. But it was in 1988 at New York University's School of Medicine that the main event occurred: the development of a monoclonal antibody against the inflammation-inducing molecule tumour necrosis factor (TNF). As Vilcek and others revealed, people with rheumatoid arthritis had high levels of TNF. Remicade was the first TNF-blocking agent approved by the US Food and Drug Administration, initially for treating Crohn's disease, in 1998. Today, it is used against multiple autoimmune conditions, including rheumatoid arthritis and psoriasis, and remains one of the world's five top-selling prescription drugs.

Vilcek hymns the importance to medicine of fundamental science, serendipity, collegiality and some risk-taking. He supports funding for translational medicine, but cautions that without continued support for basic research, there might be nothing to translate. However, the book's early detail about science, clinical trials and intellectual-property processes behind Remicade could be intimidating to those who picked up the autobiography for its personal tale. Love and Science becomes more engaging in its second section, when it steps back to the memories of a Jewish boy born in the year that Adolf Hitler came to power in Germany.

It is a tale of ingenuity and near misses. Vilcek's mother officially converted to Catholicism in 1939, his father in 1942, allowing both to be exempted from the Czechoslovakian government's punitive measures against Jews. They placed Jan in a Catholic orphanage at the age of eight, in a further attempt to keep him from being deported. Through several moves and periods of separation, the family survived the Second World War, and re-established a comfortable lifestyle in Bratislava in 1945. The democratic republic of Czechoslovakia had been reinstated after years of occupation and division during the war, but upheaval returned in 1948 when the Communist Party gained political power and quickly imposed a totalitarian system.

Vilcek decided early on to pursue research. He joined the Institute of Virology immediately after graduating from medical school in 1957, and soon published a single-author paper in Nature (J. Vilcek Nature 187, 73–74; 1960). The young scientist doggedly established contacts with Western researchers, and these efforts paid off when he and Marica defected in 1964. Carrying no official documents, they were waved across the border from Austria to West Germany — a scene rendered poignant in light of the current European refugee crisis. The ease with which Vilcek procured job offers from US colleagues is also hard to imagine now. He joined New York University as an assistant professor with no interview, a beneficiary of the US government's competitive research investments during the cold war.

The final section of the book I found the most original. Here, Vilcek reverts to the story of Remicade's success, and his unexpected wealth. His first quarterly royalty payment in 1999 was just less than his annual salary as a professor; by 2005, the portion of his future royalties pledged to New York University was projected to eventually reach more than US$105 million. At first, Jan and Marica ate at restaurants and caught taxis more often; they helped family and friends, and replaced their second-hand furniture with European art-deco pieces. But they had no interest in luxury living, so as the royalties grew, they established what would become the Vilcek Foundation in 2000.

They began by supporting their workplaces, the New York University School of Medicine and the Metropolitan Museum of Art. They endowed professorships, lab space, scholarships and curatorships, earning a place among the top 15 US philanthropists of 2005. After the terrorist attacks of 11 September 2001, they began to see chinks in the US welcome for foreigners. Accordingly, in 2006 they launched annual Vilcek Prizes to recognize extraordinary achievements by immigrants to the United States in biomedical science and the arts and humanities. Aware that many of their prizewinners, from cancer biologist Joan Massagué to cellist Yo-Yo Ma, were already lauded, the Vilceks established annual prizes “for creative promise” in 2009 to honour up-and-coming talent. Prizewinners so far have included the Iranian-American scientist Pardis Sabeti, for her work on pathogen evolution (see N. L. Yozwiak Nature 518, 477–479; 2015).

This story is told humbly, with honest insight into the deliberations between the Vilceks and generous credit to the many people who have advised them. The couple clearly delights in following the careers of the awardees. Jan Vilcek is now in his early eighties, and he mentions in Love and Science how he and Marica have made provision for the foundation to continue when they can no longer administer it. One senses that he is happy with his legacy, both scientific and benevolent.

Author information

Affiliations

Authors

Related links

Related links

Related links in Nature Research

Immunology: Magic bullets to blockbusters

Virology: Journal of the plague years

Autoimmunity: When the body betrays

History of medicine: Typhus and tyranny

Related external links

The Vilcek Foundation

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Turner, M. Drug discovery: A life of tumult and triumph. Nature 530, 157–158 (2016). https://doi.org/10.1038/530157a

Download citation

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing