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Fibroblasts for all seasons

Connective-tissue cells known as fibroblasts display an increasing spectrum of functions. Different fibroblast subtypes are now shown to either promote or suppress inflammation-associated intestinal cancers.

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Figure 1: Fibroblast functions in inflammation-associated colorectal cancer.


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  1. Öhlund, D., Elyada, E. & Tuveson, D. J. Exp. Med. 211, 1503–1523 (2014).

    Article  Google Scholar 

  2. Pallangyo, C. K., Ziegler, P. K. & Greten, F. R. J. Exp. Med. 212, 2253–2266 (2015).

    CAS  Article  Google Scholar 

  3. Koliaraki, V., Pasparakis, M. & Kollias, G. J. Exp. Med. 212, 2235–2251 (2015).

    CAS  Article  Google Scholar 

  4. DiDonato, J. A., Mercurio, F. & Karin, M. Immunol. Rev. 246, 379–400 (2012).

    Article  Google Scholar 

  5. Armaka, M. et al. J. Exp. Med. 205, 331–337 (2008).

    CAS  Article  Google Scholar 

  6. Greten, F. R. et al. Cell 118, 285–296 (2004).

    CAS  Article  Google Scholar 

  7. Andreu, P. et al. Cancer Cell 17, 121–134 (2010).

    CAS  Article  Google Scholar 

  8. Erez, N., Truitt, M., Olson, P., Arron, S. T. & Hanahan, D. Cancer Cell 17, 135–147 (2010).

    CAS  Article  Google Scholar 

  9. Driskell, R. R. & Watt, F. M. Trends Cell Biol. 25, 92–99 (2015).

    CAS  Article  Google Scholar 

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Correspondence to Erwin F. Wagner.

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Wagner, E. Fibroblasts for all seasons. Nature 530, 42–43 (2016).

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