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Neurobiology

Pull out the stops for plasticity

The strength of synaptic connections between neurons needs to be variable, but not too much so. Evidence now indicates that regulation of such synaptic plasticity involves a complex cascade of feedback loops.

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Figure 1: The promotion of plasticity.

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References

  1. Tigaret, C. M., Olivio, V., Sadowski, J. H. L. P., Ashby, M. C. & Mellor, J. R. Nature Commun. http://dx.doi.org/10.1038/ncomms10289 (2016).

  2. Wang, H. & Zhuo, M. Front. Pharmacol. 3, 189 (2012).

    PubMed  PubMed Central  Google Scholar 

  3. Bloodgood, B. L. & Sabatini, B. L. Curr. Opin. Neurobiol. 17, 345–351 (2007).

    Article  CAS  Google Scholar 

  4. Ngo-Anh, T. J., Bloodgood, B. L., Lin, M., Sabatini, B. L., Maylie, J. & Adelman, J. P. Nature Neurosci. 8, 642–649 (2005).

    Article  CAS  Google Scholar 

  5. Buchanan, K. A., Petrovic, M. M., Chamberlain, S. E. L., Marrion, N. V. & Mellor, J. R. Neuron 68, 948–963 (2010).

    Article  CAS  Google Scholar 

  6. Giessel, A. J. & Sabatini, B. L. Neuron 68, 936–947 (2010).

    Article  CAS  Google Scholar 

  7. Brzosko, Z., Schultz, W. & Paulsen, O. eLife 4, e09685 (2015).

    Article  Google Scholar 

  8. Yu, X. M., Askalan, R., Keil, G. J. & Salter, M. W. Science 275, 674–678 (1997).

    Article  CAS  Google Scholar 

  9. Lu, Y. M., Roder, J. C., Davidow, J. & Salter, M. W. Science 279, 1363–1367 (1998).

    Article  CAS  ADS  Google Scholar 

  10. Benquet, P., Gee, C. E. & Gerber, U. J. Neurosci. 22, 9679–9686 (2002).

    Article  CAS  Google Scholar 

  11. Nevian, T. & Sakmann, B. J. Neurosci. 26, 11001–11013 (2006).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Thomas G. Oertner.

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Gee, C., Oertner, T. Pull out the stops for plasticity. Nature 529, 164–165 (2016). https://doi.org/10.1038/529164a

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