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Host protein clips bird flu's wings in mammals


The polymerase enzyme from avian influenza A viruses does not function well in human cells. The protein ANP32A has been identified as the cellular factor mediating a major component of this host restriction. See Letter p.101

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Figure 1: A cellular factor for host restriction.


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Correspondence to Anice C. Lowen.

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Influenza: Pathways to human adaptation

Virology: Bird flu in mammals

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Lowen, A. Host protein clips bird flu's wings in mammals. Nature 529, 30–31 (2016).

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