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In retrospect

Twenty-five years of the sex-determining gene

The discovery that the gene SRY on the mammalian Y chromosome drives testis development marked a turning point in the decades-long quest to understand the genetic underpinnings and evolution of sex determination.

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Figure 1: An evolving understanding of sex.

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Correspondence to Jennifer A. Marshall Graves.

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Graves, J. Twenty-five years of the sex-determining gene. Nature 528, 343–344 (2015). https://doi.org/10.1038/528343a

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