Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Metabolism

Light on leptin link to lipolysis

Cutting-edge experiments show that the hormone leptin, which is secreted by fat cells, promotes fat loss by activating the release of catecholamine signalling molecules from neurons wrapped around the fat cells.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Sympathetic to fat loss.

Notes

  1. See all news & views

References

  1. Zeng, W. et al. Cell 163, 84–94 (2015).

    Article  CAS  Google Scholar 

  2. Zhang, Y. et al. Nature 372, 425–432 (1994).

    Article  ADS  CAS  Google Scholar 

  3. Friedman, J. M. & Halaas, J. L. Nature 395, 763–770 (1998).

    Article  ADS  CAS  Google Scholar 

  4. Bartness, T. J., Liu, Y., Shrestha, Y. B. & Ryu, V. Front. Neuroendocrinol. 35, 473–493 (2014).

    Article  CAS  Google Scholar 

  5. Chung, K. et al. Nature 497, 332–337 (2013).

    Article  ADS  CAS  Google Scholar 

  6. Ke, M.-T., Fujimoto, S. & Imai, T. Nature Neurosci. 16, 1154–1161 (2013).

    Article  CAS  Google Scholar 

  7. Sharpe, J. et al. Science 296, 541–545 (2002).

    Article  ADS  CAS  Google Scholar 

  8. Sohal, V. S., Zhang, F., Yizhar, O. & Deisseroth, K. Nature 459, 698–702 (2009).

    Article  ADS  CAS  Google Scholar 

  9. Atasoy, D., Aponte, Y., Su, H. H. & Sternson, S. M. J. Neurosci. 28, 7025–7030 (2008).

    Article  CAS  Google Scholar 

  10. Gettys, T. W., Harkness, P. J. & Watson, P. M. Endocrinology 137, 4054–4057 (1996).

    Article  CAS  Google Scholar 

  11. Myers, M. G. Jr & Olson, D. P. Nature 491, 357–363 (2012).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Johan Ruud or Jens C. Brüning.

Related links

Related links

Related links in Nature Research

Metabolism: Let them eat fat

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ruud, J., Brüning, J. Light on leptin link to lipolysis. Nature 527, 43–44 (2015). https://doi.org/10.1038/527043a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/527043a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing