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Chemical biology

Protein modification in a trice

Organometallic reagents have been developed that chemically modify proteins and peptides specifically at cysteine amino-acid residues — potentially offering a general route to making therapeutically useful compounds. See Letter p.687

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Figure 1: Site-selective reactions with proteins.

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References

  1. 1

    Vinogradova, E. V., Zhang, C., Spokoyny, A. M., Pentelute, B. L. & Buchwald, S. L. Nature 526, 687–691 (2015).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Duncan, R. Nature Rev. Drug Discov. 2, 347–360 (2003).

    CAS  Article  Google Scholar 

  3. 3

    Alconcel, S. N. S., Baas, A. S. & Maynard, H. D. Polym. Chem. 2, 1442–1448 (2011).

    CAS  Article  Google Scholar 

  4. 4

    Wu, A. M. Methods 65, 139–147 (2014).

    CAS  Article  Google Scholar 

  5. 5

    Chari, R. V. J., Miller, M. L. & Widdison, W. C. Angew. Chem. Int. Edn 53, 3796–3827 (2014).

    CAS  Article  Google Scholar 

  6. 6

    Fishburn, C. S. J. Pharm. Sci. 97, 4167–4183 (2008).

    CAS  Article  Google Scholar 

  7. 7

    Antos, J. M. & Francis, M. B. Curr. Opin. Chem. Biol. 10, 253–262 (2006).

    CAS  Article  Google Scholar 

  8. 8

    Boutureira, O. & Bernardes, G. J. L. Chem. Rev. 115, 2174–2195 (2015).

    CAS  Article  Google Scholar 

  9. 9

    He, Y., Chen, D. & Zheng, W. Oncogene http://dx.doi.org/10.1038/onc.2015.37 (2015).

  10. 10

    Lyon, R. P. et al. Nature Biotechnol. 32, 1059–1062 (2014).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Heather Maynard.

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Maynard, H. Protein modification in a trice. Nature 526, 646–647 (2015). https://doi.org/10.1038/526646b

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