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Molecular biology

Mediating transcription and RNA export

The finding that the Mediator protein complex contributes to messenger RNA export from the nucleus in yeast adds to a growing list of roles for the complex in regulating transcriptional processes.

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Figure 1: Complex interactions in messenger RNA export.

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References

  1. Schneider, M. et al. Cell 162, 1016–1028 (2015).

    Article  CAS  Google Scholar 

  2. Allen, B. L. & Taatjes, D. J. Nature Rev. Mol. Cell Biol. 16, 155–166 (2015).

    Article  CAS  Google Scholar 

  3. Kohler, A., Schneider, M., Cabal, G. G., Nehrbass, U. & Hurt, E. Nature Cell Biol. 10, 707–715 (2008).

    Article  Google Scholar 

  4. D'Urso, A. & Brickner, J. H. Trends Genet. 30, 230–236 (2014).

    Article  CAS  Google Scholar 

  5. Chen, J. et al. RNA 18, 2148–2156 (2012).

    Article  CAS  Google Scholar 

  6. Huang, Y. et al. Mol. Cell 45, 459–469 (2012).

    Article  CAS  Google Scholar 

  7. Mukundan, B. & Ansari, A. J. Biol. Chem. 288, 11384–11394 (2013).

    Article  CAS  Google Scholar 

  8. Koschubs, T. et al. EMBO J. 28, 69–80 (2009).

    Article  CAS  Google Scholar 

  9. Green, D. M. et al. J. Biol. Chem. 277, 7752–7760 (2002).

    Article  CAS  Google Scholar 

  10. Yu, M. C. et al. Genes Dev. 18, 2024–2035 (2004).

    Article  CAS  Google Scholar 

  11. Therizols, P. et al. Science 346, 1238–1242 (2014).

    Article  ADS  CAS  Google Scholar 

  12. Tan-Wong, S. M., Wijayatilake, H. D. & Proudfoot, N. J. Genes Dev. 23, 2610–2624 (2009).

    Article  CAS  Google Scholar 

  13. Kagey, M. H. et al. Nature 467, 430–435 (2010).

    Article  ADS  CAS  Google Scholar 

Download references

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Correspondence to Dylan J. Taatjes.

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Rubin, J., Taatjes, D. Mediating transcription and RNA export. Nature 526, 199–200 (2015). https://doi.org/10.1038/526199a

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