Research Highlights | Published:

Medical microbiology

Lung pathogen evolves in isolation

Nature volume 524, page 391 (27 August 2015) | Download Citation

Bacteria that infect the lungs of people with cystic fibrosis evolve into different forms in various parts of the lungs.

Pradeep Singh at the University of Washington in Seattle and his team dissected the infected lungs of ten people with the disease who were having lung transplants, and analysed the genomes of Pseudomonas aeruginosa bacteria sampled from different areas of the lung. Comparing areas that were mildly and severely diseased, the team found distinct lineages of the bacterium with variations in virulence, antibiotic resistance and other factors. They conclude that this diversity arose because bacterial cells became isolated in lung regions where they then evolved separately.

This regional diversification could enhance resistance to drugs and human defences, the authors say.

Cell Host Microbe http://doi.org/6zw (2015)

About this article

Publication history

Published

DOI

https://doi.org/10.1038/524391c

Authors

    Comments

    By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

    Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing