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Dengue virus

Bumps in the road to therapeutic antibodies

A human antibody against dengue virus serotype 2 has been shown to protect mice against disease. Structures of the antibody bound to the virus illuminate how it binds different viral forms to prevent virus entry into cells.

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Figure 1: Surface structure affects antibody binding.


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  1. Bhatt, S. et al. Nature 496, 504–507 (2013).

    Article  CAS  ADS  Google Scholar 

  2. Murphy, B. R. & Whitehead S. S. Annu. Rev. Immunol. 29, 587–619 (2011).

    Article  CAS  Google Scholar 

  3. Fibriansah, G. et al. Science 349, 88–91 (2015).

    Article  CAS  ADS  Google Scholar 

  4. Kuhn, R. J. et al. Cell 108, 717–725 (2002).

    Article  CAS  Google Scholar 

  5. Fibriansah, G. et al. J. Virol. 87, 7585–7592 (2013).

    Article  CAS  Google Scholar 

  6. Zhang, X. et al. Proc. Natl Acad. Sci. USA 110, 6795–6799 (2013).

    Article  CAS  ADS  Google Scholar 

  7. de Alwis, R. et al. Proc. Natl Acad Sci. USA 109, 7439–7444 (2012).

    Article  CAS  ADS  Google Scholar 

  8. Burke, D. S., Nisalak, A., Johnson, D. E. & Scott, R. M. Am. J. Trop. Med. Hyg. 38, 172–180 (1988).

    Article  CAS  Google Scholar 

  9. Halstead, S. B. Adv. Virus Res. 60, 421–467 (2003).

    Article  CAS  Google Scholar 

  10. Dejnirattisai, W. et al. Nature Immunol. 16, 170–177 (2015).

    Article  CAS  Google Scholar 

  11. Rouvinski, A. et al. Nature 520, 109–113 (2015).

    Article  CAS  ADS  Google Scholar 

  12. Dowd, K. A. & Pierson, T. C. Virology 411, 306–315 (2011).

    Article  CAS  Google Scholar 

  13. Kuhn, R. J., Dowd, K. A., Post, C. B. & Pierson, T. C. Virology 479–480, 508–517 (2015).

    Article  Google Scholar 

  14. Teoh, E. P. et al. Sci. Transl. Med. 4, 139ra83 (2012).

  15. Kaufmann, B. et al. Proc. Natl Acad. Sci. USA 107, 18950–18955 (2010).

    Article  CAS  ADS  Google Scholar 

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Correspondence to Theodore C. Pierson.

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Goo, L., Pierson, T. Bumps in the road to therapeutic antibodies. Nature 524, 295–296 (2015).

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