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Dengue virus

Bumps in the road to therapeutic antibodies

A human antibody against dengue virus serotype 2 has been shown to protect mice against disease. Structures of the antibody bound to the virus illuminate how it binds different viral forms to prevent virus entry into cells.

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Figure 1: Surface structure affects antibody binding.

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Correspondence to Theodore C. Pierson.

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Goo, L., Pierson, T. Bumps in the road to therapeutic antibodies. Nature 524, 295–296 (2015). https://doi.org/10.1038/524295a

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