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Mapping the path to a longer life

Inhibiting the PI3K branch of the cell signalling induced by insulin and insulin-like growth factor can extend lifespan. The finding that inhibiting the RAS branch also extends lifespan in flies suggests a new target for anti-ageing drugs.

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Figure 1: IIS and lifespan.


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  1. Kenyon, C. Phil. Trans. R. Soc. B 366, 9–16 (2011).

    Article  CAS  Google Scholar 

  2. Hwangbo, D. S. et al. Nature 429, 562–566 (2004).

    Article  ADS  CAS  Google Scholar 

  3. Slack, C. et al. Cell 162, 72–83 (2015).

    Article  CAS  Google Scholar 

  4. Suh, Y. et al. Proc. Natl Acad. Sci. USA 105, 3438–3442 (2008).

    Article  ADS  CAS  Google Scholar 

  5. Willcox, B. J. et al. Proc. Natl Acad. Sci. USA 105, 13987–13992 (2008).

    Article  ADS  CAS  Google Scholar 

  6. Blüher, M., Kahn, B. B. & Kahn, C. R. Science 299, 572–574 (2003).

    Article  ADS  Google Scholar 

  7. Kappeler, L. et al. PLoS Biol. 6, e254 (2008).

    Article  Google Scholar 

  8. Guevara-Aguirre, J. et al. Science Transl. Med. 3, 70ra13 (2011).

    Article  Google Scholar 

  9. Thorpe, L. M., Yuzugullu, H. & Zhao, J. J. Nature Rev. Cancer 15, 7–24 (2015).

    Article  CAS  Google Scholar 

  10. Alic, N. et al. PLoS Genet. 10, e1004619 (2014).

    Article  Google Scholar 

  11. Banks, A. S. et al. Nature 517, 391–395 (2015).

    Article  ADS  CAS  Google Scholar 

  12. Anisimov, V. N. & Bartke, A. Crit. Rev. Oncol. Hematol. 87, 201–223 (2013).

    Article  Google Scholar 

  13. Fontana, L., Partridge, L. & Longo, V. D. Science 328, 321–326 (2010).

    Article  ADS  CAS  Google Scholar 

  14. Brandhorst, S. et al. Cell Metab. 22, 86–99 (2015).

    Article  CAS  Google Scholar 

  15. Harrison, D. E. et al. Nature 460, 392–395 (2009).

    Article  ADS  CAS  Google Scholar 

  16. Harrison, D. E. et al. Aging Cell 13, 273–282 (2014).

    Article  CAS  Google Scholar 

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Correspondence to Morris F. White.

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White, M. Mapping the path to a longer life. Nature 524, 170–171 (2015).

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