Table 3 Family-based bi-allelic association test results for the dinucleotide repeat (CA)n polymorphisms of IFNγ intron 1 at position 1349–1373 show that 13-CA repeats allele is preferentially transmitted to the affected individuals

From: Role of interferon-γ gene polymorphisms in susceptibility to IgA nephropathy: a family-based association study

IFNγ CA repeat 1349-1373 Allele frequency Fam a S b E(S) c Var(S) d Z P
Allele size (bp)
131 17 0.005 1 −0.66 0.00 0.16 −1.63 0.10
129 16 0.005 0 0.00 0.00 0.00   
127 15 0.05 7 −0.66 −0.46 0.63 −0.26 0.79
125 14 0.10 15 −2.29 −0.00 1.88 −1.66 0.09
123 13 0.42 40 6.98 0.003 6.58 2.72 0.006e
121 12 0.41 38 −1.45 1.99 5.74 −1.43 0.15
119 11 0.01 1 0.00 0.00 0.16 0.00 1.0
  1. aNumber of informative families (ie families with at least one heterozygous parent).
  2. bStatistic test from family–based association test for the observed number of transmitted alleles.
  3. cExpected value of S under the null hypothesis (ie no linkage or association).
  4. dEmpirical variance.
  5. eBonferroni P-value=0.04.