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Molecular biology

DNA replication reconstructed

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Chromosomes must be faithfully duplicated in each cell-division cycle to ensure genome integrity. The in vitro reconstitution of DNA-replication initiation in yeast allows mechanistic studies of this fundamental process. See Article p.431

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Figure 1: DNA-replication initiation.

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  • 26 March 2015

    This story was published online with the wrong standfirst. The text has now been corrected.


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  1. Yeeles, J. T. P., Deegan, T. D., Janska, A., Early, A. & Diffley, J. F. X. Nature 519, 431–435 (2015).

    Article  ADS  CAS  Google Scholar 

  2. Waga, S. & Stillman, B. Annu. Rev. Biochem. 67, 721–751 (1998).

    Article  CAS  Google Scholar 

  3. Heller, R. C. et al. Cell 146, 80–91 (2011).

    Article  CAS  Google Scholar 

  4. Li, Y. & Araki, H. Genes Cells 18, 266–277 (2013).

    Article  CAS  Google Scholar 

  5. Labib, K. Genes Dev. 24, 1208–1219 (2010).

    Article  CAS  Google Scholar 

  6. Remus, D. et al. Cell 139, 719–730 (2009).

    Article  CAS  Google Scholar 

  7. Sun, J. et al. Nature Struct. Mol. Biol. 20, 944–951 (2013).

    Article  CAS  Google Scholar 

  8. Yardimci, H. & Walter, J. C. Nature Struct. Mol. Biol. 21, 20–25 (2014).

    Article  CAS  Google Scholar 

  9. Costa, A. et al. Nature Struct. Mol. Biol. 18, 471–477 (2011).

    Article  CAS  Google Scholar 

  10. Fu, Y. V. et al. Cell 146, 931–941 (2011).

    Article  CAS  Google Scholar 

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Correspondence to Michael Weinreich.

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Weinreich, M. DNA replication reconstructed. Nature 519, 418–419 (2015).

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