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Chemical biology

How to minimalize antibodies

The success of antibodies as pharmaceuticals has triggered interest in crafting much smaller mimics. A crucial step forward has been taken with the chemical synthesis of small molecules that recruit immune cells to attack cancer cells.

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Figure 1: Bridging target and effector cells.


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  1. Reichert, J. M. mAbs 7, 1–8 (2015).

    Article  CAS  Google Scholar 

  2. McEnaney, P. J. et al. J. Am. Chem. Soc. 136, 18034–18043 (2014).

    Article  CAS  Google Scholar 

  3. Rader, C. Trends Biotechnol. 32, 186–197 (2014).

    Article  CAS  Google Scholar 

  4. McEnaney, P. J., Parker, C. G., Zhang, A. X. & Spiegel, D. A. ACS Chem. Biol. 7, 1139–1151 (2012).

    Article  CAS  Google Scholar 

  5. Dennis, M. S. et al. J. Biol. Chem. 277, 35035–35043 (2002).

    Article  CAS  Google Scholar 

  6. Kodadek, T. Curr. Opin. Chem. Biol. 14, 713–720 (2010).

    Article  CAS  Google Scholar 

  7. Frankel, S. R. & Baeuerle, P. A. Curr. Opin. Chem. Biol. 17, 385–392 (2013).

    Article  CAS  Google Scholar 

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Correspondence to Christoph Rader.

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Rader, C. How to minimalize antibodies. Nature 518, 38–39 (2015).

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