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CRISPR engineering turns on genes

The repurposing of a bacterial defence system known as CRISPR into a potent activator of gene expression in human cells enables powerful studies of gene function, as exemplified in cancer cells. See Article p.583

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Figure 1: RNAs as modular scaffolds for gene regulation.


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Correspondence to Howard Y. Chang.

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Cho, S., Chang, H. CRISPR engineering turns on genes. Nature 517, 560–562 (2015).

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