Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Regenerative biology

The versatile and plastic liver

There is conflicting evidence about which cell type is responsible for liver regeneration following damage. It emerges that duct-like progenitor cells arise from hepatocytes after liver damage, a finding that reconciles previous data.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Regeneration of the liver.

References

  1. Tarlow, B. D. et al. Cell Stem Cell 15, 605–618 (2014).

    Article  CAS  Google Scholar 

  2. Schaub, J. R., Malato, Y., Gormond, C. & Willenbring, H. Cell Rep. 8, 933–939 (2014).

    Article  CAS  Google Scholar 

  3. Yanger, K. et al. Cell Stem Cell 15, 340–349 (2014).

    Article  CAS  Google Scholar 

  4. Fausto, N., Campbell, J. S. & Riehle, K. J. Hepatology 43, S45–S53 (2006).

    Article  CAS  Google Scholar 

  5. Evarts, R. P., Nagy, P., Nakatsukasa, H., Marsden, E. & Thorgeirsson, S. S. Cancer Res. 49, 1541–1547 (1989).

    CAS  PubMed  Google Scholar 

  6. Choi, T.-Y., Ninov, N., Stainier, D. Y. R. & Shin, D. Gastroenterology 146, 776–788 (2014).

    Article  CAS  Google Scholar 

  7. Boulter, L., Lu, W.-Y. & Forbes S. J. J. Clin. Invest. 123, 1867–1873 (2013).

    Article  CAS  Google Scholar 

  8. Shin, S. et al. Genes Dev. 25, 1185–1192 (2011).

    Article  CAS  Google Scholar 

  9. Huch, M. et al. Nature 494, 247–250 (2013).

    Article  CAS  ADS  Google Scholar 

  10. Gouw, A. S. H., Clouston, A. D. & Theise, N. D. Hepatology 54, 1853–1863 (2011).

    Article  Google Scholar 

  11. Michalopoulos, G. K., Barua, L. & Bowen, W. C. Hepatology 41, 535–544 (2005).

    Article  CAS  Google Scholar 

  12. Hattoum, A., Rubin, E., Orr, A. & Michalopoulos, G. K. Hum. Pathol. 44, 743–749 (2013).

    Article  CAS  Google Scholar 

  13. Vilarinho, S. & Lifton, R. P. Cell 150, 1096–1099 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Meritxell Huch.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Huch, M. The versatile and plastic liver. Nature 517, 155–156 (2015). https://doi.org/10.1038/517155a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/517155a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing