Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Organic synthesis

Better chemistry through radicals

Subjects

An iron catalyst has been developed that mediates bond formation between a wide range of alkene reactants, opening up short synthetic routes to compounds that were previously accessible only through arduous pathways. See Article p.343

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Iron-catalysed carbon–carbon bond formation with unprecedented functional-group tolerance.

References

  1. Lo, J. C., Gui, J., Yabe, Y., Pan, C.-M. & Baran, P. S. Nature 516, 343–348 (2014).

    Article  ADS  CAS  Google Scholar 

  2. de Meijere, A. & Diederich, F. (eds) Metal-Catalyzed Cross-Coupling Reactions 2nd edn (Wiley, 2004).

    Book  Google Scholar 

  3. Nakamura, E. et al. Org. React. 83, Ch. 1, 1–209 (2014).

    MathSciNet  CAS  Google Scholar 

  4. Kato, K. & Mukaiyama, T. Chem. Lett. 21, 1137–1140 (1992).

    Article  Google Scholar 

  5. Lo, J. C., Yabe, Y. & Baran, P. S. J. Am. Chem. Soc. 136, 1304–1307 (2014).

    Article  CAS  Google Scholar 

  6. Rowlands, G. J. Tetrahedron 65, 8603–8655 (2009).

    Article  CAS  Google Scholar 

  7. Rowlands, G. J. Tetrahedron 66, 1593–1636 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Steven L. Castle.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Castle, S. Better chemistry through radicals. Nature 516, 332–333 (2014). https://doi.org/10.1038/516332a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/516332a

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing