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Tolerance lies in the timing

During immune-cell development, potentially self-reactive T cells are eliminated. It emerges that recruitment of a co-receptor bound to the T-cell receptor by the enzyme Lck is the rate-limiting step in this negative selection.

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Figure 1: Dwell time determines selection outcomes in thymocytes.


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Correspondence to Nicholas R. J. Gascoigne.

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Gascoigne, N. Tolerance lies in the timing. Nature 515, 502–503 (2014).

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