Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer

Antitumour immunity gets a boost

Subjects

Five papers extend the list of cancers that respond to therapies that restore antitumour immunity by blocking the PD-1 pathway, and characterize those patients who respond best. See Letters p.558, p.563, p.568, p.572 & p.577

This is a preview of subscription content, access via your institution

Access options

Buy this article

Purchase on Springer Link

Instant access to full article PDF

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Checkpoint blockade activates antitumour immunity.

References

  1. Coley, W. B. Proc. R. Soc. Med. 3, 1–48 (1910).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Dunn, G. P., Bruce, A. T., Ikeda, H., Old, L. J. & Schreiber, R. D. Nature Immunol. 3, 991–998 (2002).

    CAS  Google Scholar 

  3. Koebel, C. M. et al. Nature 450, 903–907 (2007).

    Article  ADS  CAS  Google Scholar 

  4. Shankaran, V. et al. Nature 410, 1107–1111 (2001).

    Article  ADS  CAS  Google Scholar 

  5. Powles, T. et al. Nature 515, 558–562 (2014).

    Article  ADS  CAS  Google Scholar 

  6. Herbst, R. S. et al. Nature 515, 563–567 (2014).

    Article  ADS  CAS  Google Scholar 

  7. Tumeh, P. C. et al. Nature 515, 568–571 (2014).

    Article  ADS  CAS  Google Scholar 

  8. Yadav, M. et al. Nature 515, 572–576 (2014).

    Article  ADS  CAS  Google Scholar 

  9. Gubin, M. M. et al. Nature 515, 577–581 (2014).

    Article  ADS  CAS  Google Scholar 

  10. Page, D. B., Postow, M. A., Callahan, M. K., Allison, J. P. & Wolchok, J. D. Annu. Rev. Med. 65, 185–202 (2014).

    Article  CAS  Google Scholar 

  11. Robert, C. et al. Lancet 384, 1109–1117 (2014).

    Article  CAS  Google Scholar 

  12. Topalian, S. L. et al. J. Clin. Oncol. 32, 1020–1030 (2014).

    Article  CAS  Google Scholar 

  13. Wolchok, J. D. et al. Ann. Oncol. 24, 2174–2180 (2013).

    Article  CAS  Google Scholar 

  14. Brahmer, J. R. et al. N. Engl. J. Med. 366, 2455–2465 (2012).

    Article  CAS  Google Scholar 

  15. Topalian, S. L. et al. N. Engl. J. Med. 366, 2443–2454 (2012).

    Article  CAS  Google Scholar 

  16. Hamid, O. et al. N. Engl. J. Med. 369, 134–144 (2013).

    Article  CAS  Google Scholar 

  17. Taube, J. M. et al. Sci. Transl. Med. 4, 127ra37 (2012).

    Article  Google Scholar 

  18. Brahmer, J. R. et al. J. Clin. Oncol. 28, 3167–3175 (2010).

    Article  CAS  Google Scholar 

  19. Matsushita, H. et al. Nature 482, 400–404 (2012).

    Article  ADS  CAS  Google Scholar 

  20. Duan, F. et al. J. Exp. Med. 211, 2231–2248 (2014).

    Article  Google Scholar 

  21. Snyder, A. et al. N. Engl. J. Med. http://dx.doi.org/10.1056/NEJMoa1406498 (2014).

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jedd D. Wolchok.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wolchok, J., Chan, T. Antitumour immunity gets a boost. Nature 515, 496–498 (2014). https://doi.org/10.1038/515496a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/515496a

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer