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Potency needs constancy

In a finding that highlights ways to optimize the efficacy of antibody-based therapeutics and vaccines, the activity of potent HIV-1-neutralizing antibodies has been confirmed to depend on cellular binding to the antibodies' Fc regions.

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Figure 1: Antibody-mediated viral control.


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Correspondence to Alexandra Trkola.

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Trkola, A. Potency needs constancy. Nature 514, 442–443 (2014).

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