Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Relax and come in

During inflammation, lymph nodes swell with an influx of immune cells. New findings identify a signalling pathway that induces relaxation in the contractile cells that give structure to these organs. See Letter p.498

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Lymph-node swelling during the inflammatory response.


  1. Low, B. C. et al. FEBS Lett. 588, 2663–2670 (2014).

    Article  CAS  Google Scholar 

  2. Yang, C.-Y. et al. Proc. Natl Acad. Sci. USA 111, E109–E118 (2014).

    Article  CAS  Google Scholar 

  3. Acton, S. E. et al. Nature 514, 498–502 (2014).

    Article  ADS  CAS  Google Scholar 

  4. Mionnet, C. et al. Blood 118, 6115–6122 (2011).

    Article  CAS  Google Scholar 

  5. Luther, S. A., Vogt, T. K. & Siegert, S. Immunol. Lett. 138, 9–11 (2011).

    Article  CAS  Google Scholar 

  6. Peduto, L. et al. J. Immunol. 182, 5789–5799 (2009).

    Article  CAS  Google Scholar 

  7. Cabanac, A., Folkow, L. P. & Blix, A. S. J. Appl. Physiol. 82, 1989–1994 (1997).

    Article  CAS  Google Scholar 

  8. McHale, N. G. & Thornbury, K. D. Exp. Physiol. 75, 847–850 (1990).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Michael Sixt.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vaahtomeri, K., Sixt, M. Relax and come in. Nature 514, 441–442 (2014).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing