Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Neurological disorders

Quality-control pathway unlocked

A modified ubiquitin protein has been identified by three independent studies as the missing link in a cellular quality-control pathway that is implicated in Parkinson's disease. See Letter p.162

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: PINK1 and parkin in mitochondrial quality control.

References

  1. Valente, E. M. et al. Science 304, 1158–1160 (2004).

    ADS  CAS  Article  Google Scholar 

  2. Kitada, T. et al. Nature 392, 605–608 (1998).

    ADS  CAS  Article  Google Scholar 

  3. Kane, L. A. et al. J. Cell Biol. 205, 143–153 (2014).

    CAS  Article  Google Scholar 

  4. Kazlauskaite, A. et al. Biochem. J. 460, 127–139 (2014).

    CAS  Article  Google Scholar 

  5. Koyano, F. et al. Nature 510, 162–166 (2014).

    ADS  CAS  Article  Google Scholar 

  6. Jin, S. M. et al. J. Cell Biol. 191, 933–942 (2010).

    CAS  Article  Google Scholar 

  7. Narendra, D. P. et al. PLoS Biol. 8, e1000298 (2010).

    Article  Google Scholar 

  8. Clark, I. E. et al. Nature 441, 1162–1166 (2006).

    ADS  CAS  Article  Google Scholar 

  9. Park, J. et al. Nature 441, 1157–1161 (2006).

    ADS  CAS  Article  Google Scholar 

  10. Shiba-Fukushima, K. et al. Sci. Rep. 2, 1002 (2012).

    Article  Google Scholar 

  11. Wauer, T. & Komander, D. EMBO J. 32, 2099–2112 (2013).

    CAS  Article  Google Scholar 

  12. Trempe, J. F. et al. Science 340, 1451–1455 (2013).

    ADS  CAS  Article  Google Scholar 

  13. Poole, A. C. et al. Proc. Natl Acad. Sci. USA 105, 1638–1643 (2008).

    ADS  CAS  Article  Google Scholar 

  14. Ziviani, E., Tao, R. N. & Whitworth, A. J. Proc. Natl Acad. Sci. USA 107, 5018–5023 (2010).

    ADS  CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Asa Abeliovich.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Abeliovich, A. Quality-control pathway unlocked. Nature 510, 44–45 (2014). https://doi.org/10.1038/510044a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/510044a

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing