Figure 1: HCV trajectory. | Nature

Figure 1: HCV trajectory.

From: Treatment triumphs

Figure 1

In the 1980s, mysterious cases of liver inflammation following blood transfusions that were not explained by hepatitis A or hepatitis B viral infections were treated using type I interferon proteins, with a success rate of around 5%. The cause of these infections was identified in 1989 as RNA virus hepatitis C (HCV). The combination of PEGylated interferon (PEG-IFN) and ribavirin, approved in 2002, improved cure rates to around 50%. By 2011, drug cocktails containing HCV-specific direct-acting antivirals (DAAs) were being used to treat patients, with around 75% cure rates, and recent clinical trials5,6,7,8,9,10,11 of all-oral, interferon-free, DAA-based regimens have increased treatment success rates to more than 95%.

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