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Immunology

To affinity and beyond

Tracking B cells in germinal centres — hotspots of B-cell proliferation and mutation during an immune response — reveals that those cells presenting the most antigen on their surface are programmed to dominate. See Letter p.637

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Figure 1: Selection in the germinal centre.

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Correspondence to David M. Tarlinton.

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Tarlinton, D. To affinity and beyond. Nature 509, 573–574 (2014). https://doi.org/10.1038/509573a

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