Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Synthetic biology

Construction of a yeast chromosome

Nature volume 509, pages 168–169 (2014)Cite this article

Subjects

One aim of synthetic biology is to generate complex synthetic organisms. Now, a stage in this process has been achieved in yeast cells — an entire yeast chromosome has been converted to a synthetic sequence in a stepwise manner.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Building synthetic genomes.

References

  1. Gibson, D. G. et al. Science 329, 52–56 (2010).

    Article  CAS  ADS  Google Scholar 

  2. Annaluru, N. et al. Science 344, 55–58 (2014).

    Article  CAS  ADS  Google Scholar 

  3. Gibson, D. G. et al. Proc. Natl Acad. Sci. USA 105, 20404–20409 (2008).

    Article  CAS  ADS  Google Scholar 

  4. Gibson, D. G. et al. Science 319, 1215–1220 (2008).

    Article  CAS  ADS  Google Scholar 

  5. Gibson, D. G. et al. Nature Methods 6, 343–345 (2009).

    Article  CAS  Google Scholar 

  6. Annaluru, N. et al. Methods Mol. Biol. 852, 77–95 (2012).

    Article  CAS  Google Scholar 

  7. Isaacs, F. J. et al. Science 333, 348–353 (2011).

    Article  CAS  ADS  Google Scholar 

  8. Glass, J. I., Hutchison, C. A. III, Smith, H. O. & Venter, J. C. Mol. Syst. Biol. 5, 330 (2009).

    Article  Google Scholar 

  9. Lartigue, C. et al. Science 325, 1693–1696 (2009).

    Article  CAS  ADS  Google Scholar 

  10. Lartigue, C. et al. Science 317, 632–638 (2007).

    Article  CAS  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Daniel G. Gibson and J. Craig Venter are at the J. Craig Venter Institute, La Jolla, California 92037, USA, and at Synthetic Genomics, La Jolla.,

    Daniel G. Gibson & J. Craig Venter

Authors
  1. Daniel G. Gibson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Craig Venter
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Daniel G. Gibson.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gibson, D., Venter, J. Construction of a yeast chromosome. Nature 509, 168–169 (2014). https://doi.org/10.1038/509168a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/509168a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research