Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Metabolism

Targeting a fat-accumulation gene

An enzyme that links two metabolic hubs has been found to be upregulated in the fat cells of overweight mice. Inhibition of the gene encoding this enzyme protects mice from diet-induced obesity. See Letter p.258

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Accelerating fat-cell metabolism.

References

  1. Kraus, D. et al. Nature 508, 258–262 (2014).

    ADS  CAS  Article  Google Scholar 

  2. Ghanta, S., Grossmann, R. E. & Brenner, C. Crit. Rev. Biochem. Mol. Biol. 48, 561–574 (2013).

    CAS  Article  Google Scholar 

  3. Abel, E. D. et al. Nature 409, 729–733 (2001).

    ADS  CAS  Article  Google Scholar 

  4. Yang, Q. et al. Nature 436, 356–362 (2005).

    ADS  CAS  Article  Google Scholar 

  5. Lee, Y. H. et al. Diabetologia 48, 1776–1783 (2005).

    CAS  Article  Google Scholar 

  6. Bogan, K. L. & Brenner, C. Annu. Rev. Nutr. 28, 115–130 (2008).

    CAS  Article  Google Scholar 

  7. Aksoy, S., Szumlanski, C. L. & Weinshilboum, R. M. J. Biol. Chem. 269, 14835–14840 (1994).

    CAS  PubMed  Google Scholar 

  8. Lu, S. C. Int. J. Biochem. Cell Biol. 32, 391–395 (2000).

    CAS  Article  Google Scholar 

  9. Jell, J. et al. J. Biol. Chem. 282, 8404–8413 (2007).

    CAS  Article  Google Scholar 

  10. Pirinen, E. et al. Mol. Cell. Biol. 27, 4953–4967 (2007).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Charles Brenner.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Brenner, C. Targeting a fat-accumulation gene. Nature 508, 194–195 (2014). https://doi.org/10.1038/508194a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/508194a

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing