The gene CYLD is so named because one of its mutant forms is associated with cylindromatosis, which causes skin tumours.

The CYLD protein is an enzyme; its active site in humans contains a cysteine residue at position 601 (denoted as C in the one-letter amino-acid code). The amino-acid sequence following this cysteine (C) is tyrosine (Y), leucine (L) and aspartate (D). What are the odds of that?