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Tuberculosis

Drug discovery goes au naturel

Nature volume 506, pages 436–437 (2014)Cite this article

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A Correction to this article was published on 16 April 2014

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In a study that showcases the potential of semisynthetic drug design, structural modification of an existing antibiotic with little activity against Mycobacterium tuberculosis has generated a new class of effective antitubercular lead.

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Figure 1: Natural complexity.

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References

  1. Lee, R. E. et al. Nature Med. http://dx.doi.org/10.1038/nm.3458 (2014).

  2. Borovinskaya, M. A., Shoji, S., Holton, J. M., Fredrick, K. & Cate, J. H. ACS Chem. Biol. 2, 545–552 (2007).

    Article  CAS  Google Scholar 

  3. Newman, D. J. & Cragg, G. M. J. Nat. Prod. 75, 311–335 (2012).

    Article  CAS  Google Scholar 

  4. Fox, W., Ellard, G. A. & Mitchison, D. A. Int. J. Tuberc. Lung Dis. 3, S231–S279 (1999).

    CAS  PubMed  Google Scholar 

  5. Sensi, P. Rev. Infect. Dis. 5, S402–S406 (1983).

    Article  CAS  Google Scholar 

  6. Balganesh, M. et al. Antimicrob. Agents Chemother. 56, 2643–2651 (2012).

    Article  CAS  Google Scholar 

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  1. Clifton E. Barry is in the Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-3206, USA.,

    Clifton E. Barry

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  1. Clifton E. Barry
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Correspondence to Clifton E. Barry.

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Barry, C. Drug discovery goes au naturel. Nature 506, 436–437 (2014). https://doi.org/10.1038/506436a

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