The discovery that most CD4+ T cells killed during HIV infection die through a process known as pyroptosis may provide long-sought explanations for HIV-associated T-cell depletion and inflammation. See Article p.509
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References
Gottlieb, M. S. et al. N. Engl. J. Med. 305, 1425–1431 (1981).
Doitsh, G. et al. Nature 505, 509–514 (2014).
Miao, E. A. et al. Immunol. Rev. 243, 206–214 (2011).
Ho, D. D. et al. Nature 373, 123–126 (1995).
Wei, X. et al. Nature 373, 117–122 (1995).
Veazey, R. S. et al. Science 280, 427–431 (1998).
Brenchley, J. M. et al. Nature Med. 12, 1365–1371 (2006).
Silvestri, G. et al. Immunity 8, 441–452 (2003).
Doitsh, G. et al. Cell 143, 789–801 (2010).
Monroe, K. M. et al. Science http://dx.doi.org/10.1126/science.1243640 (2013).
Latz, E. et al. Nature Rev. Immunol. 13, 397–411 (2013).
Lamkanfi, M. et al. J. Leuk. Biol. 82, 220–225 (2007).
Mallat, Z. et al. Circulation 104, 1598–1603 (2001).
Iannello, A. et al. Curr. HIV Res. 8, 147–164 (2010).
Watanabe, D. et al. Viral Immunol. 23, 619–625 (2010).
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Cox, A., Siliciano, R. Not-so-innocent bystanders. Nature 505, 492–493 (2014). https://doi.org/10.1038/505492a
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DOI: https://doi.org/10.1038/505492a
