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Stem cells

Sex specificity in the blood

Haematopoietic stem cells, from which blood cells originate, are shown to respond to oestrogen and divide more frequently in female mice than in males, probably preparing females for the increased demand for blood in pregnancy. See Letter p.555

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Figure 1: Oestrogen regulates stem-cell cycling.

References

  1. 1

    Nakada, D., Levi, B. P. & Morrison, S. J. Neuron 70, 703–718 (2011).

    CAS  Article  Google Scholar 

  2. 2

    Shingo, T. et al. Science 299, 117–120 (2003).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Ray, R. et al. Mol. Med. 14, 493–501 (2008).

    CAS  Article  Google Scholar 

  4. 4

    Deasy, B. M. et al. J. Cell Biol. 177, 73–86 (2007).

    CAS  Article  Google Scholar 

  5. 5

    Nakada, D. et al. Nature 505, 555–558 (2014).

    ADS  CAS  Article  Google Scholar 

  6. 6

    Illing, A. et al. Haematologica 97, 1131–1135 (2012).

    CAS  Article  Google Scholar 

  7. 7

    Orford, K. W. & Scadden, D. T. Nature Rev. Genet. 9, 115–128 (2008).

    CAS  Article  Google Scholar 

  8. 8

    Mandal, P. K., Blanpain, C. & Rossi, D. J. Nature Rev. Mol. Cell Biol. 12, 198–202 (2011).

    CAS  Article  Google Scholar 

  9. 9

    Mohrin, M. et al. Cell Stem Cell 7, 174–185 (2010).

    CAS  Article  Google Scholar 

  10. 10

    Nielsen, J. H., Svensson, C., Galsgaard, E. D., Møldrup, A. & Billestrup, N. J. Mol. Med. 77, 62–66 (1999).

    CAS  Article  Google Scholar 

  11. 11

    Notta, F., Doulatov, S. & Dick, J. E. Blood 115, 3704–3707 (2010).

    CAS  Article  Google Scholar 

  12. 12

    Baerlocher, G. M. et al. Blood 114, 219–222 (2009).

    CAS  Article  Google Scholar 

  13. 13

    Jain, A. & Naniwadekar, M. BMC Hematol. 13, 10 (2013).

    Article  Google Scholar 

Download references

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Correspondence to Anne Brunet.

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Leeman, D., Brunet, A. Sex specificity in the blood. Nature 505, 488–489 (2014). https://doi.org/10.1038/505488a

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