Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Ringside views

Two crystal structures reveal that the Vif and Vpx proteins of human and simian immunodeficiency viruses mediate evasion of host defences by reprogramming the cellular protein-degradation machinery. See Letters p.229 & p.234

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: Destruction of host-cell antiviral proteins.


  1. Malim, M. H. & Bieniasz, P. D. Cold Spring Harb. Perspect. Med. 2, a006940 (2012).

    Article  Google Scholar 

  2. Guo, Y. et al. Nature 505, 229–233 (2014).

    Article  ADS  CAS  Google Scholar 

  3. Schwefel, D. et al. Nature 505, 234–238 (2014).

    Article  ADS  CAS  Google Scholar 

  4. Baldauf, H.-M. et al. Nature Med. 18, 1682–1689 (2012).

    Article  CAS  Google Scholar 

  5. Zimmerman, E. S., Schulman, B. A. & Zheng, N. Curr. Opin. Struct. Biol. 20, 714–721 (2010).

    Article  CAS  Google Scholar 

  6. Jäger, S. et al. Nature 481, 371–375 (2012).

    Article  ADS  Google Scholar 

  7. Zhang, W., Du, J., Evans, S. L., Yu, Y. & Yu, X.-F. Nature 481, 376–379 (2012).

    Article  ADS  CAS  Google Scholar 

  8. Lim, E. S. et al. Cell Host Microbe 11, 194–204 (2012).

    Article  CAS  Google Scholar 

  9. Goldstone, D. C. et al. Nature 480, 379–382 (2011).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Michael H. Malim.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Malim, M. Ringside views. Nature 505, 167–168 (2014).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing