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Detective work on drug dosage

Patients differ in their requirement for, and response to, various drug doses. A general platform that allows continuous monitoring of drug levels in the blood of rats may open the door to patient-specific dosing.

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  1. Ferguson, B. S. et al. Sci. Transl. Med. 5, 213ra165 (2013).

    Article  Google Scholar 

  2. Xiao, Y., Lubin, A. A., Heeger, A. J. & Plaxco, K. W. Angew. Chem. Int. Edn 44, 5456–5459 (2005).

    CAS  Article  Google Scholar 

  3. Lubin, A. A. & Plaxco, K. W. Acc. Chem. Res. 43, 496–505 (2010).

    CAS  Article  Google Scholar 

  4. Osborne, S. E., Matsumura, I. & Ellington, A. D. Curr. Opin. Chem. Biol. 1, 5–9 (1997).

    CAS  Article  Google Scholar 

  5. Swenson, J. S. et al. J. Am. Chem. Soc. 131, 4262–4266 (2009).

    Article  Google Scholar 

  6. Ueda, Y. et al. Chem. Pharm. Bull. 37, 1639–1641 (1989).

    CAS  Article  Google Scholar 

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Correspondence to Richard M. Crooks.

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Crooks, R. Detective work on drug dosage. Nature 505, 165–166 (2014).

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