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Therapeutics

Detective work on drug dosage

Nature volume 505, pages 165–166 (2014)Cite this article

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Patients differ in their requirement for, and response to, various drug doses. A general platform that allows continuous monitoring of drug levels in the blood of rats may open the door to patient-specific dosing.

Choosing the right drug dose for a particular patient is more of an art than a science. For example, the dosage of most drugs is simply based on patients' age: “Adults and children 12 years and over, take 2 tablespoons every 6 hours,” for example. In reality, there is patient-to-patient variability in drug metabolism and excretion, highlighting the need for accurate and patient-specific approaches to monitor drug concentration after administration. Taking a big step towards this goal, Ferguson et al.1 describe, in a paper published in Science Translational Medicine, a detection system that allows real-time tracking of drugs in the blood.

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References

  1. Ferguson, B. S. et al. Sci. Transl. Med. 5, 213ra165 (2013).

    Article  Google Scholar 

  2. Xiao, Y., Lubin, A. A., Heeger, A. J. & Plaxco, K. W. Angew. Chem. Int. Edn 44, 5456–5459 (2005).

    CAS  Article  Google Scholar 

  3. Lubin, A. A. & Plaxco, K. W. Acc. Chem. Res. 43, 496–505 (2010).

    CAS  Article  Google Scholar 

  4. Osborne, S. E., Matsumura, I. & Ellington, A. D. Curr. Opin. Chem. Biol. 1, 5–9 (1997).

    CAS  Article  Google Scholar 

  5. Swenson, J. S. et al. J. Am. Chem. Soc. 131, 4262–4266 (2009).

    Article  Google Scholar 

  6. Ueda, Y. et al. Chem. Pharm. Bull. 37, 1639–1641 (1989).

    CAS  Article  Google Scholar 

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  1. Richard M. Crooks is in the Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712-1224, USA.,

    Richard M. Crooks

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  1. Richard M. Crooks
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Correspondence to Richard M. Crooks.

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Crooks, R. Detective work on drug dosage. Nature 505, 165–166 (2014). https://doi.org/10.1038/505165a

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