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Molecular biology

Antibiotic re-frames decoding

Ketolide antibiotics have been found to induce a ribosomal frameshift — a change in the way that RNA is translated — in bacteria. This promotes the expression of a gene for antibiotic resistance, and may have broader implications.

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Figure 1: Antibiotic-induced frameshifting.


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Correspondence to John F. Atkins or Pavel V. Baranov.

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Atkins, J., Baranov, P. Antibiotic re-frames decoding. Nature 503, 478–479 (2013).

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