Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


Sculpting neuronal connectivity

It emerges that a transcription program differentially regulates inhibitory inputs in distinct neuronal compartments — an unexpected coordinated switch for achieving experience-dependent 'plasticity' in neural circuits. See Letter p.121

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Subcellular-specific regulation of neuronal activity.


  1. Turrigiano, G. G. Cell 135, 422–435 (2008).

    Article  CAS  Google Scholar 

  2. Bloodgood, B. L., Sharma, N., Browne, H. A., Trepman, A. Z. & Greenberg, M. E. Nature 503, 121–125 (2013).

    Article  CAS  ADS  Google Scholar 

  3. Pouille, F. & Scanziani, M. Science 293, 1159–1163 (2001).

    Article  CAS  Google Scholar 

  4. West, A. E., Griffith, E. C. & Greenberg, M. E. Nature Rev. Neurosci. 3, 921–931 (2002).

    Article  CAS  Google Scholar 

  5. Turrigiano, G. Cold Spring Harb. Perspect. Biol. 4, a005736 (2012).

    Article  Google Scholar 

  6. Lin, Y. et al. Nature 455, 1198–1204 (2008).

    Article  CAS  ADS  Google Scholar 

  7. Dieni, S. et al. J. Cell Biol. 196, 775–788 (2012).

    Article  CAS  Google Scholar 

  8. Matsuda, N. et al. J. Neurosci. 29, 14185–14198 (2009).

    Article  CAS  Google Scholar 

  9. Freund, T. F. & Buzsáki, G. Hippocampus 6, 347–470 (1996).

    Article  CAS  Google Scholar 

  10. Taniguchi, H. et al. Neuron 71, 995–1013 (2011).

    Article  CAS  Google Scholar 

  11. Bear, M. F. & Malenka, R. C. Curr. Opin. Neurobiol. 4, 389–399 (1994).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Peter Scheiffele.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sylwestrak, E., Scheiffele, P. Sculpting neuronal connectivity. Nature 503, 42–43 (2013).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing