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Sculpting neuronal connectivity

It emerges that a transcription program differentially regulates inhibitory inputs in distinct neuronal compartments — an unexpected coordinated switch for achieving experience-dependent 'plasticity' in neural circuits. See Letter p.121

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Figure 1: Subcellular-specific regulation of neuronal activity.

References

  1. Turrigiano, G. G. Cell 135, 422–435 (2008).

    Article  CAS  Google Scholar 

  2. Bloodgood, B. L., Sharma, N., Browne, H. A., Trepman, A. Z. & Greenberg, M. E. Nature 503, 121–125 (2013).

    Article  CAS  ADS  Google Scholar 

  3. Pouille, F. & Scanziani, M. Science 293, 1159–1163 (2001).

    Article  CAS  Google Scholar 

  4. West, A. E., Griffith, E. C. & Greenberg, M. E. Nature Rev. Neurosci. 3, 921–931 (2002).

    Article  CAS  Google Scholar 

  5. Turrigiano, G. Cold Spring Harb. Perspect. Biol. 4, a005736 (2012).

    Article  Google Scholar 

  6. Lin, Y. et al. Nature 455, 1198–1204 (2008).

    Article  CAS  ADS  Google Scholar 

  7. Dieni, S. et al. J. Cell Biol. 196, 775–788 (2012).

    Article  CAS  Google Scholar 

  8. Matsuda, N. et al. J. Neurosci. 29, 14185–14198 (2009).

    Article  CAS  Google Scholar 

  9. Freund, T. F. & Buzsáki, G. Hippocampus 6, 347–470 (1996).

    Article  CAS  Google Scholar 

  10. Taniguchi, H. et al. Neuron 71, 995–1013 (2011).

    Article  CAS  Google Scholar 

  11. Bear, M. F. & Malenka, R. C. Curr. Opin. Neurobiol. 4, 389–399 (1994).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Peter Scheiffele.

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Sylwestrak, E., Scheiffele, P. Sculpting neuronal connectivity. Nature 503, 42–43 (2013). https://doi.org/10.1038/503042a

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