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Metabolic syndrome

F stands for fructose and fat

Fructose and glucose have the same caloric value, but the two sugars are metabolized differently. It emerges that mice that cannot metabolize fructose are healthier when placed on carbohydrate-rich diets.

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Figure 1: Sugar metabolism.


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Correspondence to Costas A. Lyssiotis or Lewis C. Cantley.

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Competing interests

L.C.C. owns equity in, receives compensation from, and serves on the Board of Directors and Scientific Advisory Board of Agios Pharmaceuticals. Agios Pharmaceuticals is identifying metabolic pathways of cancer cells and developing drugs to inhibit such enzymes in order to disrupt tumour-cell growth and survival.

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Lyssiotis, C., Cantley, L. F stands for fructose and fat. Nature 502, 181–182 (2013).

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